Moeli o Mocha oa ho Fetola Methapo ea Kelello
Kalafo ea mabone a khubelu (RLT), haholo-holo ho near-infrared spectrum (800-1100nm), e bontša bokhoni bo ikhethang e lekalafo e thusang e sa hlaselengbakeng sa lefu la sethoathoa. Ho fapana le meriana e tloaelehileng ea ho thibela ho tsietsana e shebaneng le ts'ebetso ea li-neurotransmitter, RLT e sebetsa boemong ba sele hofetola thabo ea methapolentlafatsa ts'ebetso ea mitochondrialliseleng tsa boko tse senyehileng.
Mekhoa ea Liketso: Kamoo Leseli le ka Khutsisang Boko ba Sethoathoa
1. Pholoso ea Mitochondria
- Mosebetsi oa ho tsietsana o fokotsa ATP ka300-400%
- Leseli la 810nm le hlohlelletsa cytochrome c oxidase, le tsosolosa tlhahiso ea matla
- Lithuto tsa liphoofolo li bontšaPholoso ea ATP e potlakileng ka 40-60%kamora ho tshwarwa
2. Tšireletso ea Methapo ea Kutlo Khahlanong le Chefo e Chesang
- E fokotsa khatello ea oxidative e bakoang ke glutamate ka55%(mehlala ea in vitro)
- E eketsa li-enzyme tsa antioxidant (SOD, catalase)
- E sireletsa methapo ea kutlo ea hippocampal e kotsing ea lefu la sethoathoa sa nakoana
3. Phetoho ea Lipotoloho tsa Methapo ea Methapo
- Leseli la 660nm le fetola tekanyo ea GABA/glutamate
- Keketsehointerneuron e nang le parvalbuminmosebetsi (lisele tsa bohlokoa tse thibelang)
- E ka sitisa ts'ebetso ea ho hotetsa sebakeng sa ho tšoaroa ke sethoathoa
4. Tokiso ea Thibelo ea Mali le Boko
- Leseli le haufi le infrared le fokotsa ts'ebetso ea MMP-9
- E fokotsa ho ruruha ha post-ictal ka30%mehlala ea litoeba
Bopaki ba Bongaka: Ho tloha Lilaboratoring ho ea ho Bakuli
Liteko tsa Batho tse Tšepisang
| Thuto | Moralo | Liphihlelo tsa Bohlokoa |
|---|---|---|
| Univesithi ea Arizona (2022) | 810nm transcranial bakeng sa lefu la sethoathoa le hananang le meriana | Phokotso ea 38% ea ho tšoaroa ke sethoathoa libekeng tse 8 |
| Bongaka ba Tokyo (2020) | NIR ea ka hare ho nko bakeng sa ho tšoaroa ke sethoathoa se ka hare | Sekhahla sa ba arabelang sa 50% (>50% phokotseho ea ho tšoaroa ke sethoathoa) |
| MIT-Harvard (2023) | Sistimi ea RLT e koetsoeng | E felisitse 72% ea liketsahalo tse fumanoeng pele ho tshwarwa |
Lintlha-khōlō tsa Tlaleho ea Nyeoe
- Mosadi wa dilemo tse 28ka lefu la sethoathoa sa nakoana: RLT ea likhoeli tse 6 e eketsoa meriana →Li-seizure li fokotseha ka 62%
- Dravet syndrome ea bana: Kalafo ea letsatsi le letsatsi ea 670nm e fokotsehileng boemo ba epilepticus liketsahalo
Mekhoa ea Kalafo e Fuputsoang
Mekhoa ea ho Romela
- Lihelmete tsa Transcranial
- Leseli le pulsed la 810nm (20-40Hz)
- Metsotso e 20 ka letsatsi, makhetlo a 5 ka beke
- Lisebelisoa tsa ka hare ho nko
- E shebana le tsamaiso ea limbic ka sphenopalatine ganglion
- E sebelisoa makhetlo a 2-3 ka letsatsi bakeng sa ho sitisa aura
- Li-Optic tsa Fiber tse ka kenngoang
- Leseli la liteko le tobileng ka ho toba
- Hona jwale dithutong tsa di-primate
Liparamitha tse ntle ka ho fetisisa
- Bolelele ba maqhubu: 810nm e ithutiloe haholo bakeng sa ho kenella
- Tekanyo: 10-60J/cm² ka nako e le 'ngoe
- Ho otla ha pelo: 10-40Hz e bonts'a phetoho e ntle ka ho fetisisa ea methapo
Boemo ba Polokeho le Mehopolo
- Ha ho liketsahalo tse mpe tse tebilenge tlalehiloeng litekong
- Likotsi tsa khopolo-taba:
- Hlooho e bobebe (12% ea batho ba tšoeroeng ke lefu lena)
- Kutloisiso ea leseli la nakoana
- Lithibelo:
- Sefuba se utloang khanya ea letsatsi (maqhubu a itseng a ho phatloha ha khanya)
- Liphoso tsa lehata/li-implant
Litaelo tsa Nakong e Tlang
- Mekhoa ea ho Phekola ea Motsoako: Lijo tsa RLT + ketogenic li bontša liphello tsa tšebelisano-'moho mehlaleng ea liphoofolo
- Mekhoa ea Loop e Koetsoeng: Ho lemoha ho tshwarwa ke sethoathoa ka nako ya sebele ka ho phatloha ha lesedi ka boiketsetso
- Sepheo sa Liphatsa tsa Lefutso: Ho fetola maqhubu a maqhubu ho latela diphetoho tse itseng tsa lefu la sethoathoa (mohlala, SCN1A)
Tumellano ea Litsebi
"Leha e se tlhokomelo e tloaelehileng, phekolo ea mabone a mafubelu mohlomong e emela mokhoa o tšepisang ka ho fetisisa oa 'mele bakeng sa lefu la sethoathoa ho tloha VNS. Lilemo tse 5 tse latelang tsa liteko tsa bongaka li tla fetoha."
— Ngaka Alan Carter, Setsi sa Lipatlisiso sa Neurophotonics
Boemo ba Hona JoaleLiteko tsa Mokhahlelo oa III li ntse li tsoela pele (NCT05568290), ka tumello e ka bang teng ea FDA bakeng sa tšebeliso e eketsehileng ka 2026. Bakuli ba lokela ho buisana le lingaka tsa lefu la sethoathoa pele ba sebelisa liteko.
Marokho ana a tšimo a ntseng a fetohabiofiziksi le thuto ea methapo ea kutlo, e fanang ka tšepo bakeng sa30% ea bakuli ba lefu la sethoathoa ba sa arabeleng merianaHa lipatlisiso li ntse li tsoela pele, RLT e ka fetola tsela eo re sireletsang le ho lokisa boko bo kotsing ea ho tšoaroa ke sethoathoa.