Lefu la Alzheimer's, e leng tsoelo-pele ea neurodegenerative disorder, e iponahatsa ka matšoao a kang ho lahleheloa ke mohopolo, aphasia, agnosia, le ho se sebetse hantle ha tsamaiso. Ka tloaelo, bakuli ba tšepile meriana bakeng sa ho imolla matšoao. Leha ho le joalo, ka lebaka la mefokolo le litla-morao tse ka 'nang tsa e-ba teng tsa lithethefatsi tsena, bafuputsi ba lebisitse tlhokomelo ea bona ho phototherapy e sa hlaseleng, ho finyella katleho e kholo lilemong tsa morao tjena.
Haufinyane tjena, sehlopha se etelletsoeng pele ke Moprofesa Zhou Feifan oa Biomedical Engineering College ea Hainan University se ile sa fumana hore transcranial phototherapy e sa kopanang e ka kokobetsa matšoao a pathological le ho ntlafatsa tsebo ea kelello ho litoeba tse tsofetseng le tse nang le Alzheimer's. Sephetho sena sa bohlokoa, se phatlalalitsoeng koranteng ea Nature Communications, se fana ka leano le ts'episang la ho laola mafu a neurodegenerative.
Ho utloisisa lefu la Alzheimer's Pathology
Lebaka le tobileng la lefu la Alzheimer le ntse le sa tsejoe hantle, empa le tšoauoa ka ho kopana ho sa tloaelehang ha protheine ea beta-amyloid le neurofibrillary tangles, e lebisang ho ho se sebetse ha neuronal le ho fokotseha ha kelello. Boko, joalo ka setho sa 'mele se sebetsang ka ho fetisisa, bo hlahisa litšila tse ngata tsa metabolism nakong ea ts'ebetso ea methapo. Ho bokellana ho feteletseng ha litšila tsena ho ka senya li-neurone, ho hloka hore ho tlosoe hantle ka tsamaiso ea lymphatic.
Lijana tsa meningeal lymphatic, tse bohlokoa bakeng sa drainage ea methapo e bohareng, li bapala karolo ea bohlokoa ho tloseng liprotheine tse chefo tsa beta-amyloid, litšila tsa metabolism, le ho laola ts'ebetso ea 'mele ea ho itšireletsa mafung, e leng se etsang hore e be sepheo sa kalafo.
Phello ea Phototherapy ho Alzheimer's
Sehlopha sa Moprofesa Zhou se sebelisitse laser ea 808 nm haufi le infrared bakeng sa libeke tse 'ne tsa transcranial phototherapy ho litoeba tsa khale le tsa Alzheimer. Kalafo ena e ile ea ntlafatsa haholo ts'ebetso ea lisele tsa meningeal lymphatic endothelial, ea ntlafatsa metsi a lymphatic, 'me qetellong ea fokotsa matšoao a pathological le ho ntlafatsa ts'ebetso ea kelello ho litoeba.
Ho Khothalletsa Mosebetsi oa Neuronal ka Phototherapy
Phtotherapy e ka ntlafatsa le ho ntlafatsa ts'ebetso ea neuronal ka mekhoa e fapaneng. Mohlala, ts'ebetso ea 'mele ea ho itšireletsa mafung e bapala karolo ea bohlokoa ho lefu la Alzheimer's. Liphuputso tsa morao-rao li bonts'a hore mahlaseli a 532 nm green laser a ka matlafatsa ts'ebetso ea lisele tsa 'mele oa ho itšireletsa mafung, a etsa hore ho be le mekhoa e ka hare ea methapo e bohareng, ho ntlafatsa 'dementia' ea methapo, le ho matlafatsa matla a phallo ea mali le matšoao a kliniki ho bakuli ba Alzheimer's. Lebone la pele la laser vascular rerradiation le bonts'itse lintlafatso tse kholo tsa viscosity ea mali, plasma viscosity, aggregation ea lisele tse khubelu tsa mali le liteko tsa neuropsychological.
Kalafo e khubelu le ea infrared (photobiomodulation) e sebelisoang libakeng tsa 'mele (mokokotlo le maoto) e ka kenya tšebetsong lisele tsa' mele tsa 'mele kapa mekhoa ea ts'ireletso ea lisele tsa stem, e tlatsetsang ho pholoheng ha neuronal le ho hlahisa liphatsa tsa lefutso tse molemo.
Tšenyo ea oxidative le eona ke ts'ebetso ea bohlokoa ea mafu ho nts'etsopele ea Alzheimer's. Lipatlisiso li fana ka maikutlo a hore mabone a mafubelu a khanyang a ka eketsa ts'ebetso ea ATP ea lisele tsa cellular, a baka phetoho ea metabolic ho tloha glycolysis ho ea ho mitochondrial microglia e anngoeng ke oligomeric beta-amyloid, e matlafatsang li-microglia tse khahlanong le ho ruruha, ho fokotsa li-cytokine tse thibelang ho ruruha, le ho kenya tšebetsong phagocytosis ho thibela neuronal. lefu.
Ho ntlafatsa ho falimeha, tlhokomeliso, le tlhokomelo e tsitsitseng ke mokhoa o mong o sebetsang oa ho ntlafatsa boleng ba bophelo ba bakuli ba Alzheimer. Bafuputsi ba fumane hore ho pepesetsoa khanya e putsoa ea maqhubu a makhutšoane ho na le phello e ntle ts'ebetsong ea kelello le taolo ea maikutlo. Ho khantša leseli le leputsoa ho ka khothalletsa mosebetsi oa potoloho ea methapo, ho susumetsa mosebetsi oa acetylcholinesterase (AchE) le choline acetyltransferase (Chat), kahoo ho ntlafatsa bokhoni ba ho ithuta le ho hopola.
Liphello tse Ntle tsa Phototherapy ho Li-Neurons tsa Boko
Sehlopha se ntseng se hola sa lipatlisiso tse matla se tiisa litlamorao tse ntle tsa phototherapy tšebetsong ea neuron ea boko. E thusa ho kenya tšebetsong mekhoa ea ts'ireletso ea lisele tsa 'mele ea ho itšireletsa mafung, e khothaletsa ho pholoha ha liphatsa tsa lefutso tsa neuronal, le ho leka-lekanya maemo a mefuta ea oksijene e sebetsang ea mitochondrial. Liphuputso tsena li theha motheo o tiileng oa lits'ebetso tsa bongaka tsa phototherapy.
Ho ipapisitsoe le lintlha tsena, Setsi sa Lipatlisiso sa MERICAN Optical Energy, ka tšebelisano le sehlopha sa Jeremane le liunivesithi tse ngata, lipatlisiso le litsi tsa bongaka, se ile sa etsa phuputso e amang batho ba lilemo tse 30-70 ba nang le bokooa bo fokolang ba kelello, ho fokotseha ha mohopolo, ho fokotsa kutloisiso le kahlolo, le bokgoni ba ho ithuta bo fokotsehileng. Barupeluoa ba ile ba latela litataiso tsa bophelo bo botle le bophelo bo botle ha ba ntse ba etsa phototherapy ka phaposing ea bophelo ea MERICAN, ka mefuta le litekanyetso tse sa fetoheng tsa meriana.
Ka mor'a likhoeli tse tharo tsa liteko tsa neuropsychological, litlhahlobo tsa boemo ba kelello, le litlhahlobo tsa kelello, liphetho li bontšitse ntlafatso e kholo ho lintlha tsa MMSE, ADL, le HDS har'a basebelisi ba bophelo bo botle ba cabin phototherapy. Barupeluoa ba boetse ba na le tlhokomelo e ntlafalitsoeng ea pono, boleng ba boroko, le matšoenyeho a fokotsehileng.
Liphuputso tsena li fana ka maikutlo a hore phototherapy e ka sebetsa e le phekolo e tšehetsang ho laola tšebetso ea lisele tsa boko, ho kokobetsa neuroinflammation le mafu a amanang le eona, ho ntlafatsa kutloisiso, le ho ntlafatsa mohopolo. Ho feta moo, e bula mekhoa e mecha ea hore phototherapy e fetohe mokhoa oa ho thibela kalafo.
