Lefu la Alzheimer's, e leng lefu le ntseng le tsoela pele ho senyeha ha methapo, le iponahatsa ka matšoao a kang ho lahleheloa ke mohopolo, aphasia, agnosia, le ho se sebetse hantle ha tsamaiso. Ka setso, bakuli ba 'nile ba itšetleha ka meriana bakeng sa ho imolla matšoao. Leha ho le joalo, ka lebaka la mefokolo le litla-morao tse ka bang teng tsa meriana ena, bafuputsi ba lebisitse tlhokomelo ea bona ho phekolo ea phototherapy e sa keneng ka har'a 'mele, ba fihlela katleho e kholo lilemong tsa morao tjena.
Haufinyane tjena, sehlopha se etelletsoeng pele ke Moprofesa Zhou Feifan ho tsoa Kolecheng ea Boenjiniere ba Biomedical ea Hainan University se fumane hore kalafo ea ho fofonela ka ntle ho ho kopana le boko e ka fokotsa matšoao a pathological le ho ntlafatsa bokhoni ba ho nahana ho litoeba tse tsofetseng le tse tšoeroeng ke Alzheimer's. Phihlello ena e ncha, e phatlalalitsoeng koranteng ea Nature Communications, e fana ka leano le tšepisang la ho laola mafu a methapo.
Ho Utloisisa Pathology ea Lefu la Alzheimer
Sesosa sa Alzheimer's ha se so hlake hantle, empa se khetholloa ka ho kopana ha protheine ea beta-amyloid ho sa tloaelehang le ho hohlana ha neurofibrillary, e leng se lebisang ho se sebetseng hantle ha methapo ea kutlo le ho fokotseha ha tsebo. Boko, joalo ka setho se sebetsang ka ho fetisisa 'meleng, bo hlahisa litšila tse ngata tsa metabolism nakong ea ts'ebetso ea methapo ea kutlo. Ho bokellana ho feteletseng ha litšila tsena ho ka senya li-neuron, ho hloka hore ho tlosoe ka katleho tsamaisong ea lymphatic.
Methapo ea lymphatic ea meningeal, ea bohlokoa bakeng sa ho ntša metsi tsamaisong ea methapo e bohareng, e bapala karolo ea bohlokoa ho hloekiseng liprotheine tse chefo tsa beta-amyloid, litšila tsa metabolism, le ho laola ts'ebetso ea 'mele ea ho itšireletsa mafung, e leng se etsang hore e be sepheo sa kalafo.
Tšusumetso ea Phototherapy ho Alzheimer's
Sehlopha sa Moprofesa Zhou se sebelisitse laser ea 808 nm e haufi le infrared ka libeke tse 'ne tsa phekolo ea phototherapy ea transcranial e sa amaneng le litoeba tse tsofetseng le tsa Alzheimer's. Kalafo ena e ntlafalitse haholo ts'ebetso ea lisele tsa endothelial tsa meningeal lymphatic, e ntlafalitse phallo ea mali ea lymphatic, 'me qetellong e fokolitse matšoao a pathological le mesebetsi e ntlafetseng ea kelello litoebeng.
Ho Ntlafatsa Mosebetsi oa Neuronal ka Phototherapy
Kalafo ea phtotherapy e ka ntlafatsa le ho ntlafatsa ts'ebetso ea methapo ea kutlo ka mekhoa e fapaneng. Mohlala, ts'ebetso ea 'mele ea ho itšireletsa mafung e bapala karolo ea bohlokoa ho pathology ea Alzheimer's. Lithuto tsa morao tjena li bontša hore mahlaseli a 532 nm a laser e tala a ka matlafatsa ts'ebetso ea sele ea 'mele ea ho itšireletsa mafung, a baka mekhoa ea mantlha li-neuron tse tebileng tsa bohareng, a ntlafatsa 'dementia' ea methapo ea mali, 'me a ntlafatsa matla a phallo ea mali le matšoao a bongaka ho bakuli ba Alzheimer's. Mahlaseli a pele a methapo ea mali a laser e tala a bontšitse ntlafatso e kholo ho viscosity ea mali, viscosity ea plasma, ho bokellana ha lisele tse khubelu tsa mali, le liteko tsa neuropsychological.
Kalafo e khubelu le e bobebe (photobiomodulation) e sebelisoang libakeng tse ka thoko tsa 'mele (mokokotlo le maoto) e ka kenya tšebetsong lisele tsa 'mele tse itšireletsang mafung kapa mekhoa ea tšireletso ea lisele tsa stem, e tlatsetsang ho pholoheng ha methapo ea kutlo le tlhahiso ea liphatsa tsa lefutso tse molemo.
Tšenyo ea oxidative le eona ke ts'ebetso ea bohlokoa ea pathological nts'etsopele ea Alzheimer's. Lipatlisiso li bontša hore mahlaseli a mafubelu a ka eketsa ts'ebetso ea ATP ea sele, a baka phetoho ea metabolism ho tloha ho glycolysis ho ea ts'ebetsong ea mitochondrial ho microglia e ruruhang e anngoeng ke oligomeric beta-amyloid, a eketsa maemo a microglia e loantšang ho ruruha, a fokotsa li-cytokine tse bakang ho ruruha, le ho kenya tšebetsong phagocytosis ho thibela lefu la methapo.
Ho ntlafatsa ho falimeha, temoho le tlhokomelo e tsitsitseng ke mokhoa o mong o sebetsang oa ho ntlafatsa boleng ba bophelo ba bakuli ba Alzheimer. Bafuputsi ba fumane hore ho pepesehela leseli le leputsoa le bolelele bo bokhutšoanyane ho ama ts'ebetso ea kelello le taolo ea maikutlo ka tsela e ntle. Mahlaseli a leseli le leputsoa a ka khothaletsa ts'ebetso ea potoloho ea methapo, a susumetsa ts'ebetso ea acetylcholinesterase (AchE) le choline acetyltransferase (ChAT), ka hona a ntlafatsa bokhoni ba ho ithuta le ba ho hopola.
Litlamorao tse Ntle tsa Phototherapy ho Li-Neuron tsa Boko
Patlisiso e ntseng e hola ea 'mele e tiisa litlamorao tse ntle tsa phototherapy mosebetsing oa neuron ea boko. E thusa ho kenya tšebetsong mekhoa ea tšireletso ea lisele tsa 'mele ea ho itšireletsa mafung, e khothalletsa tlhahiso ea liphatsa tsa lefutso tsa ho pholoha ha neuronal, le ho leka-lekanya maemo a oksijene a arabelang mitochondrial. Liphuputso tsena li theha motheo o tiileng oa lits'ebetso tsa bongaka tsa phototherapy.
Ho latela temohisiso ena, Setsi sa Lipatlisiso sa Matla a Optical sa MERICAN, ka tšebelisano 'moho le sehlopha sa Jeremane le liunivesithi tse ngata, lipatlisiso le litsi tsa bongaka, se entse phuputso e kenyeletsang batho ba lilemo li 30-70 ba nang le bothata bo fokolang ba kelello, ho fokotseha ha mohopolo, kutloisiso e fokotsehileng le kahlolo e molemo, le bokhoni bo fokotsehileng ba ho ithuta. Barupeluoa ba ile ba latela litataiso tsa lijo le tsa mokhoa o phetseng hantle oa bophelo ha ba ntse ba etsoa kalafo ea phototherapy ka kamoreng ea bophelo ea MERICAN, ka mefuta e tsitsitseng ea meriana le litekanyo.
Kamora likhoeli tse tharo tsa liteko tsa kelello, litlhahlobo tsa boemo ba kelello, le liteko tsa kelello, liphetho li bontšitse ntlafatso e kholo lintlheng tsa MMSE, ADL, le HDS har'a basebelisi ba phototherapy ea likamore tsa bophelo bo botle. Barupeluoa ba boetse ba bile le tlhokomelo e ntlafalitsoeng ea pono, boleng ba boroko, le matšoenyeho a fokotsehileng.
Liphuputso tsena li bontša hore phekolo ea phototherapy e ka sebetsa e le phekolo e tšehetsang ho laola ts'ebetso ea lisele tsa boko, ho fokotsa ho ruruha ha methapo le mafu a amanang le eona, ho ntlafatsa kutloisiso le ho ntlafatsa mohopolo. Ho feta moo, e bula litsela tse ncha tsa hore phekolo ea phototherapy e fetohe mokhoa oa phekolo ea thibelo.
